Vitaran in Bangkok: The Korean Polynucleotide Skin Booster
There is a certain kind of skin that stops people in their tracks. Not the kind achieved by covering things up, but skin that looks genuinely healthy from within: even in tone, luminous, firm, with a quality that is hard to name but easy to recognise. In Korean aesthetics, this is the standard being pursued, and it has driven some of the most interesting innovation in regenerative medicine over the past decade.
Vitaran is one of the treatments to emerge from that pursuit. Developed by LG Chem Life Sciences, one of South Korea's leading biotechnology companies, it is a polynucleotide (PN) injectable skin booster that works by supporting the skin's own repair and regeneration mechanisms at a cellular level. It does not add volume. It does not freeze movement. It works with your skin's biology to help it produce new collagen and elastin, repair itself more effectively, and maintain the quality and resilience that gradually diminishes with age and environmental exposure.
At SKNN Clinic Bangkok, our doctors have introduced Vitaran as part of our regenerative treatment offering because it addresses something many patients notice but find difficult to describe: a gradual decline in skin quality that injectables and devices alone cannot fully resolve. This article explains what Vitaran is, how it works, and how to know whether it is the right treatment for your skin.
What Is Vitaran?
Vitaran is a professional polynucleotide-based injectable skin booster manufactured by LG Chem Life Sciences in South Korea. Its active ingredient is polynucleotide (PN) at 20mg/ml, purified DNA fragments derived from salmon and used in aesthetic medicine to support fibroblast activity, collagen and elastin production, and skin renewal.
The use of salmon-derived DNA is clinically established. Salmon DNA shares a high degree of sequence similarity with human DNA, making it biocompatible and low in immunogenicity when correctly purified. LG Chem's manufacturing process selects specific molecular weight ranges of PN to optimise both biological activity and patient comfort, including adjusting the formulation's pH and osmolarity to more closely match human skin, which reduces the stinging sensation that many patients associate with polynucleotide injections.
Vitaran is designed for skin affected by moderate wrinkles, reduced elasticity, dullness, dehydration, and visible signs of ageing. It improves skin firmness, texture, tone, and resilience while also providing secondary hydration support. It is particularly suited to larger treatment areas including the face, neck, and décolletage.
Vitaran is not a filler. It does not add volume or reshape facial contours. It is a bio-regenerative skin booster: its purpose is to activate the skin's own repair and regeneration pathways, improving how the skin functions and renews itself from within the dermis.
How Vitaran Works: The Science in Plain Language
To understand what Vitaran does, it helps to understand what polynucleotides are and why they have become one of the most discussed ingredients in regenerative aesthetics.
Polynucleotides are long-chain DNA fragments. When injected into the dermis, they work through two simultaneous mechanisms:
Receptor Activation and Fibroblast Stimulation
PN binds to A2A purinergic adenosine receptors on fibroblasts, the cells responsible for producing collagen, elastin, and the structural proteins that give skin its firmness and resilience. This binding triggers a signalling cascade that stimulates fibroblast activity, increasing the production of new collagen and elastin. The process is gradual and cumulative: the skin improves as new structural protein is laid down over weeks and months following treatment.
PN also demonstrates anti-inflammatory properties, modulating inflammatory pathways in the skin to create a calmer tissue environment. This makes Vitaran particularly valuable for skin that is reactive, environmentally stressed, or showing signs of damage from UV exposure.
Structural Support Within the Dermis
Because PN molecules have long molecular chains, they also provide a degree of physical scaffolding within the dermal matrix as they integrate into the tissue. This supports the skin's architecture while the regenerative process takes place, contributing to the improvement in firmness that patients often notice alongside the overall skin quality.
Unlike hyaluronic acid skin boosters, which work by attracting water into the tissue, polynucleotides actively instruct skin cells to produce new collagen and elastin. The improvement is not temporary plumping. It is a progressive change in how the skin is functioning and renewing itself.
What Vitaran Can Help With
Vitaran's strength is in improving the quality, health, and bio-regenerative capacity of the skin itself. It is particularly well suited to patients who notice a decline in skin quality that sits beneath what topical skincare or surface-level treatments can fully address.
Vitaran is commonly used for:
Moderate wrinkles and fine lines, particularly those related to skin thinning and reduced elasticity rather than muscle movement
Dull, flat, or tired-looking skin tone lacking radiance
Reduced skin elasticity and early to moderate loss of firmness
Dehydrated or crepey skin texture
Uneven skin texture and enlarged pores
Reactive or inflamed skin that needs calming, barrier support, and repair
Skin affected by UV exposure, pollution, and environmental damage
The face, neck, and décolletage as primary treatment areas
Hands and other selected areas, depending on the treatment protocol
Vitaran is appropriate across a wide age range. Younger patients often use it preventatively to maintain a healthy skin baseline. Patients in their forties and beyond use it to restore quality and resilience that has gradually diminished. It is suitable for all skin tones.
Vitaran is most effective for patients whose primary concern is skin quality, bio-regeneration, and resilience rather than deep structural laxity or volume loss. If lifting or volumisation is your main goal, ULTRAcel Q+ or dermal fillers are more appropriate. Your doctor will guide you toward the right combination.
Vitaran vs Rejuran: What Is the Difference?
Rejuran is the treatment most patients reference when researching Vitaran, and with good reason. Both are Korean PN-based skin boosters that work through the same core biological mechanism: A2A receptor activation on fibroblasts to stimulate collagen and elastin production, combined with structural support in the dermal matrix. They are products within the same category, not different categories.
The meaningful differences lie in manufacturing, formulation, and patient experience:
Manufacturer: Vitaran is manufactured by LG Chem Life Sciences, one of South Korea's largest and most established biotechnology companies. Rejuran is manufactured by PharmaResearch, the company that established the PN skin booster category in Korea and internationally
Molecular weight selection: LG Chem selects specific molecular weight ranges of PN in Vitaran's formulation to optimise biological activity and clinical performance
Pain profile: Vitaran's formulation is developed with adjusted pH and osmolarity to match human skin more closely, reducing the stinging sensation that patients often report with PN injections. Many patients and clinicians note Vitaran is more comfortable than Rejuran during administration
Concentration: Vitaran contains 20mg/ml polynucleotides, providing a high-concentration regenerative treatment
Neither is categorically better than the other. They suit different patients and different clinical preferences. At SKNN Clinic, our doctors assess your skin, your treatment history, and your goals before recommending the most appropriate option. The best treatment is always the one that fits your skin.
What to Expect From Your Treatment
Before Your Session: Your doctor will conduct a full skin assessment during your consultation, reviewing your concerns, medical history, and any previous treatments. This informs which areas to treat, the appropriate protocol, and how many sessions to recommend. A topical numbing cream is applied before treatment begins.
During Treatment: Vitaran is administered using a series of small injections placed into the dermis using very fine needles. The procedure typically takes 30 to 45 minutes depending on the areas being treated. The formulation is specifically developed to reduce injection discomfort, and most patients find the experience straightforward.
After Treatment: Downtime is minimal. You may notice mild redness, small injection marks, slight swelling, or occasional bruising in the treated area. These effects typically settle within a few days. Makeup can usually be applied after 24 hours if advised by your doctor. Most patients return to their normal routine the same day.
When Results Appear and How Long They Last: Polynucleotide results are gradual by nature, which reflects the biology of what is happening: your skin is producing new collagen and elastin, and that takes time. Most patients notice an early improvement in skin radiance and texture within the first few weeks. More significant improvements in elasticity, firmness, and overall skin quality develop progressively over two to three months as collagen production builds.
With a course of sessions, results can be sustained for several months. Your doctor will recommend a personalised protocol including an initial treatment plan and maintenance schedule based on your skin's response.
How Vitaran Fits Into a Broader Skin Health Routine
Vitaran works well as a standalone treatment and also integrates naturally into a broader skin health plan alongside other SKNN Clinic treatments.
With Botox: Botox addresses muscle-driven lines; Vitaran addresses the quality and bio-regenerative capacity of the skin itself. They work on different aspects of the same picture and complement each other well
With ULTRAcel Q+ or VirtueRF Microneedling: device treatments address structural laxity; Vitaran supports the cellular environment in which that improvement takes place. Sequential treatment is typically recommended rather than same-day
With Profhilo: Profhilo works primarily through deep HA-driven hydration and biostimulation; Vitaran works through PN-driven fibroblast activation and bio-regeneration. Some patients benefit from both as part of a comprehensive skin quality plan
With other skin boosters: depending on your concerns, Vitaran can be used alongside or alternated with Exosomes, Rejuran, or Sculptra. Your doctor will advise on the most appropriate sequencing
Your doctor will build a personalised plan based on your skin, your goals, and your budget. The aim is never to recommend everything at once, but to sequence treatments thoughtfully so each one performs as well as possible.
Who Is Not Suitable for Vitaran?
Vitaran is contraindicated for:
Patients with active skin infections or open wounds in the treatment area
Those with known allergies to fish or polynucleotides
Patients with bleeding disorders
Pregnant or breastfeeding women
Your doctor will review your full medical history before proceeding. Please raise any concerns about suitability during your consultation.
Frequently Asked Questions
Is Vitaran the same as Rejuran?
No, but they are in the same category. Both Vitaran and Rejuran are Korean PN (polynucleotide) injectable skin boosters that work through the same biological mechanism: stimulating fibroblasts to produce new collagen and elastin. The differences lie in manufacturer, molecular weight selection, and formulation. Vitaran is made by LG Chem Life Sciences and is specifically developed for reduced injection discomfort. Rejuran is made by PharmaResearch, which established the PN category in Korea. Your doctor will advise which suits your skin.
Is Vitaran a filler?
No. Vitaran is a bio-regenerative skin booster, not a dermal filler. It does not add volume or reshape facial contours. Its purpose is to support the skin's own repair and regeneration processes, improving quality, resilience, and the production of new collagen and elastin from within the dermis.
How is Vitaran different from Profhilo?
Profhilo is a high-concentration hyaluronic acid skin remodeller that works primarily through deep hydration and HA-driven biostimulation of collagen. Vitaran works through polynucleotides, which directly activate fibroblasts via A2A receptor binding to produce new collagen and elastin. These are different biological mechanisms, and some patients benefit from both as part of a comprehensive skin quality plan. Your doctor will advise on the most appropriate approach for your skin.
Does Vitaran contain hyaluronic acid?
No. Vitaran's active ingredient is polynucleotide (PN) at 20mg/ml. It does not contain hyaluronic acid. It provides secondary hydration support through the skin's improved function rather than through a hydrating ingredient.
How many sessions will I need?
This depends on your skin condition, the areas being treated, and your goals. Your doctor will recommend a personalised protocol during your consultation. Many patients complete an initial course of sessions followed by maintenance treatments to preserve and build on results.
When will I see results?
Most patients notice an early improvement in skin radiance and texture within the first few weeks. More significant improvements in elasticity, firmness, and overall skin quality develop progressively over two to three months as new collagen and elastin are produced. Results continue to build with each session in a course.
Can Vitaran be used around the eyes?
The under-eye area is one of the most commonly requested treatment zones for Vitaran given its sensitivity and how visibly it reflects thinning and reduced elasticity. Treatment suitability and technique in this area will always be assessed and confirmed by your doctor.
Can Vitaran be used on the neck and décolletage?
Yes. Vitaran is particularly well suited to larger treatment areas including the face, neck, and décolletage. These areas often show early signs of skin quality decline and respond well to PN-based bio-regenerative treatment.
Is there any downtime?
Downtime is minimal. You may experience mild redness, small injection marks, slight swelling, or occasional bruising, which typically settles within a few days. Most patients return to their normal routine the same day, with makeup possible after 24 hours if advised by your doctor.
Is Vitaran suitable for sensitive or reactive skin?
Yes. Vitaran's anti-inflammatory properties make it particularly appropriate for reactive or sensitive skin. The PN in Vitaran helps modulate inflammatory pathways and support the skin barrier, which can reduce reactivity over time. Your doctor will assess your skin before recommending a protocol.
Book Your Vitaran Consultation at SKNN Clinic Bangkok
If you have been noticing a gradual shift in your skin quality, a loss of radiance or elasticity, skin that feels less resilient than it used to, or changes that your skincare routine cannot fully address, Vitaran is worth a conversation.
At SKNN Clinic Bangkok, every treatment decision starts with a proper skin assessment. Our doctors will give you an honest picture of what Vitaran can and cannot do for your specific skin, and how it fits alongside or instead of other treatments in your routine.
We are located on Sukhumvit Soi 22, between BTS Asoke and BTS Phrom Phong (MRT Sukhumvit). Contact us to book your consultation.
